A panoramic view of a city skyline under a clear blue sky.
  • CEO MESSAGE
  • Management Team
  • OUR MISSION
  • Approaches of CynosBio, Inc.
  • OUTLINES OF THE COMPANY
  • OUR HISTORY
  • ACCESS

CEO MESSAGE

We, CynosBio, Inc., founded as a start-up company, which research, develop, manufacture and sell regenerative medicine, in 2015 at Hirosaki-city, Japan.
Our primary goal is to bring happiness to the lives of patients and their families. In order to realize it, our business focus is on the early advancement of innovative therapies based on regenerative medicine.

In this 21st century, numerous scientific technologies have dramatically progressed. As for the field of life science or medical science, genetics, cell-biology, protein-engineering and immuno-science are notable. We get many benefits from these sciences, such as various unique drugs and therapies using cell-culture technology.

To conduct clinical application thorough research and development of these technologies, the procedure is absolutely essential as a technology-oriented company and it is also our know-how. Recently, we have successfully received the manufacturing and sales approval from the Ministry of Health, Labour and Welfare in Japan for our regenerative medicine product “Sakracy (TR-09)”. This product, the cultivated autologous oral mucosal epithelial cell sheet, is grafted to severe ocular surface. It has been developed by academia.

Moreover, a clinical trial of the cultivated autologous chondrocyte is also in progress. This cellular matrix product (IK-01) is focused to osteoarthritis.

One of our advantages is a management skill of clinical development and sales marketing. In fact, we succussed introduction of seeds technology from academia, clinical application and its medical business.
At CynosBio, Inc., we believe and motivate that our products contribute to realize all people's healthy life and happy life with their smile.

President Hiroki ISHIKAWA

Representative Director President & CEO

Hiroki Ishikawa

this is a photo of Hiroki Ishikawa , Representative Director President & CEO

Over 30 years in drug development at Bristol-Myers Squibb Co., served as Head of Development and led approval of four products
After joining CynosBio, led the acquisition of marketing approval and insurance coverage for Sacracy in 2022

Master of Pharmacy

Director Vice President & COO

Shinji UGA

this is a photo of Shinji UGA , Director Vice President & COO

Joined the company in 2024 and is responsible for overseeing corporate strategy, capital strategy, business development, and international expansion.
Previously, led IPOs, global fundraising, and cross-border M&A at a pioneering advanced medical technology company.
Also, as a venture capitalist, invested in and supported the growth of approximately 30 life science startups.

MBA/CPA

CFO Head of Corporate Management

Kosuke Ota

this is a photo of Kosuke Ota, CFO Head of Corporate Management

Former investment banker with more than 100 M&A and capital raising advisory projects in foreign firm and has extensive experience in accounting, taxation, and business management of startups as a CPA. He promotes strategic finance from both “offensive” and “defensive” perspectives.

MBA/CPA

CTO Head of Chemistry, Manufacturing and Control

Masahiro Go

this is a photo of Masahiro Go, CTO Head of Chemistry, Manufacturing and Control

this is a photo of Masahiro Go, CTO Head of Chemistry, Manufacturing and Control
Engaged in basic biology (developmental genetics) research at universities and basic and applied regenerative medicine research at companies. Responsible for the Kobe Medical Industry Promotion Organization (FBRI), where he has led the R & D and manufacturing of our company's flagship regenerative medicine products for more than 15 years

Doctor of Science

CMO Head of Regenerative Medicine Business

Tomohiro Maruyama

this is a photo of Tomohiro Maruyama, CMO Head of Regenerative Medicine Business

He has spent 30 years in sales and marketing for Bristol-Myers Squibb Co., Ltd. He has been responsible for liver and oncology marketing. Made significant contributions to the growth strategy through the market introduction of new drugs and the expansion of their indications.

Manager of the President's office

Masahiro Matsuoka

this is a photo of Masahiro Matsuoka, Manager of the President's office

After conducting research activities at Fujitsu Laboratories, he was involved in the founding of several venture companies, including life sciences, and gained management experience. Later, he joined our company as a founding member, and supported the founding of R & D projects and business plans. Currently, he is widely involved in business promotion.

External Director

Daisuke Asahara

Served as CFO and COO at HEROZ, Inc., where he led the company’s listing on the Tokyo Stock Exchange.
Prior to that, worked in the Investment Banking Division of Goldman Sachs, primarily engaged in corporate fundraising activities.
Appointed as Outside Director of the Company in 2022.

Doctor of Business Administration(DBA)

External Director

Yoshitaka Mizuno

After serving as General Manager of the Hepatitis Division at AbbVie GK, was appointed Advisor to the company in 2022.
Prior to that, held positions including Executive Corporate Officer and Head of the New Drug Division, as well as Senior Executive Corporate Officer and Head of the Liver, Hematology, and Oncology Division at Bristol-Myers Squibb.
Appointed as Outside Director of the Company in 2024.

Director Audit and Supervisory Committee Member

Yoshiharu Nohara

Before joining the Company, served as General Manager of Marketing Planning and General Manager of Affiliated Companies at Eisai Co., Ltd., and later as Full-time Audit & Supervisory Board Member at EA Pharma Co., Ltd.
Prior to that, was engaged in prescription drug marketing and M&A at Eisai.
In the field of auditing, served as Secretary of a subcommittee of the Japan Audit & Supervisory Board Members Association, possessing deep expertise in Audit and Supervisory Committee operations.

External Director Audit and Supervisory Committee Member

Tsuneo Shimoda

Appointed Full-time Audit & Supervisory Board Member of JMDC Inc. in 2016, and Director & Audit and Supervisory Committee Member of the same company in 2019.
Appointed Audit & Supervisory Board Member of the Company in 2023, and Director & Audit and Supervisory Committee Member in 2024.

External Director Audit and Supervisory Committee Member

Kentaro Motoki

After working at Deloitte Touche Tohmatsu LLC, founded AGRI Law & Accounting Office.
Appointed Audit & Supervisory Board Member of the Company in 2023, and Director & Audit and Supervisory Committee Member in 2024.

Lawer / CPA

External Director Audit and Supervisory Committee Member

Miho Imai

After gaining experience in accounting, consulting, and audit at Mitsubishi UFJ Bank, EY ShinNihon LLC, and various consulting firms, founded Ōka Tax Corporation.
Appointed Audit & Supervisory Board Member of the Company in 2023, and Director & Audit and Supervisory Committee Member in 2024.

CPA

OUR MISSION

OUR MISSION

We'll continue to challenge the providing of break-through
regenerative therapies earlier, make it possible to recover the
happiness and smile for the patients and their families.

A panoramic view of a city skyline under a clear blue sky.

Approaches of CynosBio,
Inc.

To contribute to patients and their families resuming their daily lives and leading lives full of smiles, our company promotes the practical use of novel regenerative medical technologies in medicine.

Regenerative medicine is a new technology by which human cells are used as materials to produce the organs and tissues for transplantation. Human-derived cells include the patient’s own cells, somatic stem cells, mesenchymal stem cells, and iPS cells generated from somatic cells. For all these types of cells, research and development aiming at realizing regenerative medicine are advanced by many research institutes.

Our company forms partnerships or conducts collaborative development with these research institutes for excellent regenerative medicine technologies in Japan. First, we approached in the field of ocular surface diseases. We worked in collaboration with the Department of Ophthalmology, Kyoto Prefectural University of Medicine, which had advanced a clinical investigation or a clinical study (Advanced Medical Care B program and investigator-initiated trial) for ocular surface disease caused by intractable diseases, and submitted the results of clinical study and and trials to the Ministry of Health, Labour and Welfare to receive approval of marketing authorization.

This enabled patients to receive this treatment in hospitals. In addition, we will promote our business so that this medicine can be delivered to all patients in need of it.

Expanding the target disease fields is also one of our important goals. We also work not only on the regeneration of knee cartilage for the treatment of knee cartilage damage or knee osteoarthritis in the orthopedic field but also on the development of novel regenerative medicine technologies in the field of liver diseases, such as liver cell sheets.

Moreover, we always search for other new technologies. In the future, we will also continue to try to early provide innovative regenerative medical products to patients with these diseases and their families so that they can resume bountiful daily lives.

OUTLINES OF THE COMPANY

  • Company Name
    CynosBio, Inc.
  • President and CEO
    Hiroki Ishikawa
  • Head office location
    1-3-15 Nihonbashi Horidome-cho, Chuo-ku, TOKYO, JAPAN.
  • Establishment
    September 16, 2015
  • Share capital
    JPY 3.5 Billion (included capital surplus) as of Jul.1, 2025
  • Main business
    Development, Manufacture and Sale of Regenerative Medical products
  • Number of employees
    39 (included contract employees) as of Jul.1, 2025

OUR HISTORY

  • 2015

    Sep

    Sainojo Machida (Former President of Machida and Machida Corporation) founded Hirosaki Lifescience Innovation, Inc. and was appointed as the company president

  • Oct

    A joint development agreement on autologous cartilage chondrocyte cell processing products with collagen matrix (IK-01) was signed with the Foundation for Biomedical Research and Innovation at Kobe (FBRI).

  • 2016

    Oct

    A joint development agreement on oral mucosal epithelial sheets (TR9) using amniotic membrane was signed with FBRI.

  • 2018

    Jul

    Initiated a clinical trial of IK-01 for traumatic cartilage injuries.

  • 2020

    Oct

    Manufacturing & Selling Business License obtained.

  • 2021

    Mar

    TR9 (Sakracy®) was applied in MHLW for the manufacture and sales approval.

  • 2022

    Jan

    Approval of TR9 (Sakracy®) manufacturing and sales was received from MHLW.

  • Jul

    Capital alliance was contracted with Cyberdyne Group.

  • Jul

    Initiated a clinical trial of IK-01 for osteoarthritis of the knee (Phase2).

  • Sep

    NIH pricing listing of TR9 (Sakracy®).

  • Dec

    Hiroki Ishikawa was appointed as the company president

  • 2023

    Feb

    A joint development agreement on a cell sheet intended for the treatment of liver diseases(KCS-003) with KanonCure Inc.

  • Feb

    Launched the sales of Sakuracy®.

  • Mar

    Head office was moved to Chiyoda-ku, Tokyo

  • 2024

    Oct

    A business agreement for R&D and manufacturing of regenerative medicine with FBRI

  • 2025

    Jun

    Initiated a clinical trial of IK-01 for osteoarthritis of the knee (Phase3).

  • Feb

    Head office moved to Chuo-ku, Tokyo

  • Feb

    Changed the company name to CynosBio Inc.

Head office

1-3-15 Nihonbashi Horidome-cho, Chuo-ku, TOKYO, JAPAN.
TEL:03-6457-9861